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    Short-Term Physical Inactivity Induces Endothelial Dysfunction

    Bowden Davies, KA, Norman, JA, Thompson, A, Mitchell, KL, Harrold, JA, Halford, JCG, Wilding, JPH, Kemp, GJ, Cuthbertson, DJ and Sprung, VS (2021) Short-Term Physical Inactivity Induces Endothelial Dysfunction. Frontiers in Physiology, 12. ISSN 1664-042X

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    Abstract

    Objective: This study examined the effects of a short-term reduction in physical activity, and subsequent resumption, on metabolic profiles, body composition and cardiovascular (endothelial) function. Design: Twenty-eight habitually active (≥10,000 steps/day) participants (18 female, 10 male; age 32 ± 11 years; BMI 24.3 ± 2.5 kg/m ) were assessed at baseline, following 14 days of step-reduction and 14 days after resuming habitual activity. Methods: Physical activity was monitored throughout (SenseWear Armband). Endothelial function (flow mediated dilation; FMD), cardiorespiratory fitness ((Formula presented.) peak) and body composition including liver fat (dual-energy x-ray absorptiometry and magnetic resonance spectroscopy) were determined at each assessment. Statistical analysis was performed using one-way within subject’s ANOVA; data presented as mean (95% CI). Results: Participants decreased their step count from baseline by 10,111 steps/day (8949, 11,274; P < 0.001), increasing sedentary time by 103 min/day (29, 177; P < 0.001). Following 14 days of step-reduction, endothelial function was reduced by a 1.8% (0.4, 3.3; P = 0.01) decrease in FMD. Following resumption of habitual activity, FMD increased by 1.4%, comparable to the baseline level 0.4% (–1.8, 2.6; P = 1.00). Total body fat, waist circumference, liver fat, whole body insulin sensitivity and cardiorespiratory fitness were all adversely affected by 14 days step-reduction (P < 0.05) but returned to baseline levels following resumption of activity. Conclusion: This data shows for the first time that whilst a decline in endothelial function is observed following short-term physical inactivity, this is reversed on resumption of habitual activity. The findings highlight the need for public health interventions that focus on minimizing time spent in sedentary behavior. 2

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