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A High Fat Diet Aggravates the Age-Related Decline in Skeletal Muscle Structure and Function.

Degens, Hans and Swaminathan, Anandini and Tallis, Jason (2021) A High Fat Diet Aggravates the Age-Related Decline in Skeletal Muscle Structure and Function. Exercise and Sport Sciences Reviews. ISSN 0091-6331

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Abstract

The age-related decline in muscle function is aggravated by a high-fat diet (HFD) induced increase in fat mass. The hypothesis is that a HFD leads to a faster accumulation of intramyocellular lipids (IMCL) and an earlier onset of muscle dysfunction in old than in young-adult individuals. The IMCL accumulation is attenuated in young-adult organisms by an elevated oxidative capacity. Methionine restriction enhances mitochondrial biogenesis and is promising to combat obesity across the ages.

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