A High Fat Diet Aggravates the Age-Related Decline in Skeletal Muscle Structure and Function

Degens, Hans ORCID: https://orcid.org/0000-0001-7399-4841, Swaminathan, Anandini and Tallis, Jason (2021) A High Fat Diet Aggravates the Age-Related Decline in Skeletal Muscle Structure and Function. Exercise and Sport Sciences Reviews, 49 (4). pp. 253-259. ISSN 0091-6331

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Abstract

The age-related decline in muscle function is aggravated by a high-fat diet (HFD) induced increase in fat mass. The hypothesis is that a HFD leads to a faster accumulation of intramyocellular lipids (IMCL) and an earlier onset of muscle dysfunction in old than in young-adult individuals. The IMCL accumulation is attenuated in young-adult organisms by an elevated oxidative capacity. Methionine restriction enhances mitochondrial biogenesis and is promising to combat obesity across the ages.

Item Type:	Article
Peer-reviewed:	Yes
Date Deposited:	10 May 2021 14:24
Publisher:	American College of Sports Medicine
Additional Information:	Author accepted manuscript published by Lippincott, Williams & Wilkins on behalf of American College of Sports Medicine (ACSM).
Divisions:	Faculties > Science and Engineering
Subject terms:	0913 Mechanical Engineering, 1106 Human Movement and Sports Sciences, 1116 Medical Physiology, Sport Sciences
URI:	https://e-space.mmu.ac.uk/id/eprint/627734
DOI:	https://doi.org/10.1249/jes.0000000000000261
ISSN	0091-6331
e-ISSN	1538-3008

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