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    Sustainable Access to 5‐Amino‐Oxazoles and Thiazoles via Calcium Catalyzed Elimination‐Cyclization with Isocyanides

    Basson, Ashley James and McLaughlin, Mark Gerard (2021) Sustainable Access to 5‐Amino‐Oxazoles and Thiazoles via Calcium Catalyzed Elimination‐Cyclization with Isocyanides. ChemSusChem: chemistry and sustainability, energy and materials, 14 (7). pp. 1696-1699. ISSN 1864-5631

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    Abstract

    Herein we report a sustainable, modular, rapid and high yielding transformation to afford densely functionalized 5‐aminooxazoles and thiazoles. The reaction is tolerant to a wide range of functional groups, and is typically complete in under 30 minutes. Furthermore, the described transformation is inherently green in relation to the catalyst and solvent choice as well as producing environmentally benign alcoholic by‐products.

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