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IGF-1 colocalizes with muscle satellite cells following acute exercise in humans

Grubb, Amanda and Joanisse, Sophie and Moore, Daniel R and Bellamy, Leeann M and Mitchell, Cameron J and Phillips, Stuart M and Parise, Gianni (2013) IGF-1 colocalizes with muscle satellite cells following acute exercise in humans. Applied Physiology, Nutrition, and Metabolism, 39 (4). pp. 514-518. ISSN 1715-5312

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Abstract

<jats:p> Insulin-like growth factor-1 (IGF-1) regulates stem cell proliferation and differentiation in vitro. The aim of this study was to quantify the change in satellite cell (SC) specific IGF-1 colocalization following exercise. We observed a significant increase (p &lt; 0.05) in the percentage of SC with IGF-1 colocalization from baseline to 72 h after a bout of resistance exercise. This strongly supports a role for IGF-1 in human SC function following exercise. </jats:p>

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