e-space
Manchester Metropolitan University's Research Repository

An efficient preparation of 1,2-dihydropyridazines through a Diels-Alder/palladium-catalysed elimination sequence

Britten, TK and Akien, GR and Kemmitt, PD and Halcovitch, NR and Coote, SC (2019) An efficient preparation of 1,2-dihydropyridazines through a Diels-Alder/palladium-catalysed elimination sequence. Tetrahedron Letters, 60 (22). pp. 1498-1500. ISSN 0040-4039

[img]
Preview

Download (623kB) | Preview

Abstract

© 2019 Elsevier Ltd A convenient, scalable synthesis of 1,2-dihydropyridazines is presented, based on the Diels-Alder cycloaddition of 1-acetoxy-1,3-butadiene with a variety of azo compounds, followed by a palladium-catalysed elimination. The products are produced on multigram scale and the new method is particularly efficient and atom-economical when compared with previous preparations of 1,2-dihydropyridazines.

Impact and Reach

Statistics

Downloads
Activity Overview
16Downloads
75Hits

Additional statistics for this dataset are available via IRStats2.

Altmetric

Actions (login required)

View Item View Item