The mechanistic link between Arc/Arg3.1 expression and AMPA receptor endocytosis

Wall, MJ and Corrêa, SAL (2018) The mechanistic link between Arc/Arg3.1 expression and AMPA receptor endocytosis. Seminars in Cell and Developmental Biology, 77. pp. 17-24. ISSN 1096-3634

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Official URL: https://doi.org/10.1016/j.semcdb.2017.09.005

Abstract

© 2017 The activity-regulated cytoskeleton associated protein (Arc/Arg3.1) plays a key role in determining synaptic strength through facilitation of AMPA receptor (AMPAR) endocytosis. Although there is considerable data on the mechanism by which Arc induction controls synaptic plasticity and learning behaviours, several key mechanistic questions remain. Here we review data on the link between Arc expression and the clathrin-mediated endocytic pathway which internalises AMPARs and discuss the significance of Arc binding to the clathrin adaptor protein 2 (AP-2) and to endophilin/dynamin. We consider which AMPAR subunits are selected for Arc-mediated internalisation, implications for synaptic function and consider Arc as a therapeutic target.

Item Type:	Article
Peer-reviewed:	Yes
Date Deposited:	21 Oct 2019 14:59
Publisher:	Elsevier
Additional Information:	This is an Author Accepted Manuscript of a paper accepted for publication in Seminars in Cell and Developmental Biology, published by and copyright Elsevier.
Divisions:	Faculties > Science and Engineering Research Centres > Centre for Bioscience
Subject terms:	Science & Technology, Life Sciences & Biomedicine, Cell Biology, Developmental Biology, AMPA receptors, Arc/Arg3.1, Adaptor protein 2, Endocytosis, Rectification, CALCIUM-PERMEABLE AMPA, SYNAPTIC-TRANSMISSION, TRANSCRIPTION FACTOR, GLUTAMATE RECEPTORS, ARC PROTEIN, MOUSE MODEL, SUBUNIT, PLASTICITY, SYNAPSES, DYNAMIN, Neurons, Humans, Dynamins, Adaptor Proteins, Signal Transducing, Cytoskeletal Proteins, Receptors, AMPA, Adaptor Protein Complex 2, Clathrin, Nerve Tissue Proteins, Endocytosis, Protein Binding, Protein Transport, Neuronal Plasticity, AMPA receptors, Adaptor protein 2, Arc/Arg3.1, Endocytosis, Rectification, Adaptor Protein Complex 2, Adaptor Proteins, Signal Transducing, Clathrin, Cytoskeletal Proteins, Dynamins, Endocytosis, Humans, Nerve Tissue Proteins, Neuronal Plasticity, Neurons, Protein Binding, Protein Transport, Receptors, AMPA, 0601 Biochemistry and Cell Biology, 1114 Paediatrics and Reproductive Medicine, Developmental Biology
URI:	https://e-space.mmu.ac.uk/id/eprint/624160
DOI:	https://doi.org/10.1016/j.semcdb.2017.09.005
ISSN	1096-3634
e-ISSN	1096-3634

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