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    Acute resveratrol supplementation in coronary artery disease: towards patient stratification

    Diaz, Miguel, Degens, Hans ORCID logoORCID: https://orcid.org/0000-0001-7399-4841 and Azzawi, May ORCID logoORCID: https://orcid.org/0000-0001-6238-9777 (2020) Acute resveratrol supplementation in coronary artery disease: towards patient stratification. Scandinavian Cardiovascular Journal, 54 (1). pp. 14-19. ISSN 1401-7431

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    Abstract

    Objective: Resveratrol (RV) is a polyphenol with antioxidant, anti-inflammatory and cardio-protective properties. Our objective was to investigate whether acute supplementation with high doses of RV would improve flow-mediated dilation (FMD) and oxygen consumption (VO2) kinetics in older coronary artery disease (CAD) patients. Design: We employed a placebo-controlled, single-blind, crossover design in which ten participants (aged 66.6 ± 7.8 years) received either RV or placebo (330 mg, 3x day-1) during three consecutive days plus additional 330 mg in the morning of the fourth day with a seven-day wash-out period in-between. On the fourth day, FMD of the brachial artery and VO2 on-kinetics were determined. Results; RV improved FMD in patients who had undergone coronary artery bypass grafting (CABG; -1.4 vs. 5.0%; p=0.004), but not in those who had undergone percutaneous coronary intervention (PCI; 4.2 vs. -0.2%; NS). Conclusion: Acute high dose supplementation with RV improved FMD in patients after CABG surgery but impaired FMD in patients who underwent PCI. The revascularization method-related differential effects of RV may be due to its direct effects on endothelial-dependent dilator responses. Our findings have important implications for personalized treatment and stratification of older CAD patients.

    Item Type: Article
    Peer-reviewed: Yes
    Date Deposited: 20 Aug 2019 08:26
    Publisher: Taylor & Francis
    Additional Information: This is an Author Accepted Manuscript of a paper accepted for publication in Scandinavian Cardiovascular Journal , published by and copyright Taylor & Francis
    Divisions: Faculties > Science and Engineering
    Research Centres > Centre for Bioscience
    Research Centres > Musculoskeletal Sciences & Sport Medicine
    Subject terms: Aging, Antioxidant, Endothelial Dysfunction, Oxygen Uptake, Science & Technology, Life Sciences & Biomedicine, Cardiac & Cardiovascular Systems, Cardiovascular System & Cardiology, Antioxidant, aging, endothelial dysfunction, oxygen uptake, OXIDATIVE STRESS, MUSCLE, RESPONSIVENESS, SENESCENCE, CAPACITY, PROTECTS, KINETICS, SIRT1, FLOW, Brachial Artery, Humans, Oxygen, Treatment Outcome, Exercise Therapy, Coronary Artery Bypass, Cross-Over Studies, Single-Blind Method, Oxygen Consumption, Vasodilation, Kinetics, Aged, Middle Aged, Female, Male, Coronary Artery Disease, Percutaneous Coronary Intervention, Biomarkers, Cardiac Rehabilitation, Resveratrol, Antioxidant, aging, endothelial dysfunction, oxygen uptake, Aged, Biomarkers, Brachial Artery, Cardiac Rehabilitation, Coronary Artery Bypass, Coronary Artery Disease, Cross-Over Studies, Exercise Therapy, Female, Humans, Kinetics, Male, Middle Aged, Oxygen, Oxygen Consumption, Percutaneous Coronary Intervention, Resveratrol, Single-Blind Method, Treatment Outcome, Vasodilation, 1102 Cardiorespiratory Medicine and Haematology, Cardiovascular System & Hematology
    URI: https://e-space.mmu.ac.uk/id/eprint/623694
    DOI: https://doi.org/10.1080/14017431.2019.1657584
    ISSN 1401-7431
    e-ISSN 1651-2006

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