e-space
Manchester Metropolitan University's Research Repository

    Associations between APOE and low-density lipoprotein cholesterol genotypes and cognitive and physical capability: the HALCyon programme.

    Alfred, T, Ben-Shlomo, Y, Cooper, R ORCID logoORCID: https://orcid.org/0000-0003-3370-5720, Hardy, R, Cooper, C, Deary, IJ, Elliott, J, Gunnell, D, Harris, SE, Kivimaki, M, Kumari, M, Martin, RM, Power, C, Sayer, AA, Starr, JM, Kuh, D, Day, IN and Team, HALCyon Study (2014) Associations between APOE and low-density lipoprotein cholesterol genotypes and cognitive and physical capability: the HALCyon programme. AGE, 36 (4). ISSN 0161-9152

    [img]
    Preview
    Published Version
    Available under License Creative Commons Attribution.

    Download (306kB) | Preview

    Abstract

    The APOE ε2/3/4 genotype has been associated with low-density lipoprotein cholesterol (LDL-C) and Alzheimer disease. However, evidence for associations with measures of cognitive performance in adults without dementia has been mixed, as it is for physical performance. Associations may also be evident in other genotypes implicated in LDL-C levels. As part of the Healthy Ageing across the Life Course (HALCyon) collaborative research programme, genotypic information was obtained for APOE ε2/3/4, rs515135 (APOB), rs2228671 (LDLR) and rs629301 (SORT1) from eight cohorts of adults aged between 44 and 90 + years. We investigated associations with four measures of cognitive (word recall, phonemic fluency, semantic fluency and search speed) and physical capability (grip strength, get up and go/walk speed, timed chair rises and ability to balance) using meta-analyses. Overall, little evidence for associations between any of the genotypes and measures of cognitive capability was observed (e.g. pooled beta for APOE ε4 effect on semantic fluency z score = −0.02; 95 % CI = −0.05 to 0.02; p value = 0.3; n = 18,796). However, there was borderline evidence within studies that negative effects of APOE ε4 on nonverbal ability measures become more apparent with age. Few genotypic associations were observed with physical capability measures. The findings from our large investigation of middle-aged to older adults in the general population suggest that effects of APOE on cognitive capability are at most modest and are domain- and age-specific, while APOE has little influence on physical capability. In addition, other LDL-C-related genotypes have little impact on these traits.

    Impact and Reach

    Statistics

    Activity Overview
    6 month trend
    375Downloads
    6 month trend
    285Hits

    Additional statistics for this dataset are available via IRStats2.

    Altmetric

    Repository staff only

    Edit record Edit record