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    Positive Feedback Defines the Timing, Magnitude, and Robustness of Angiogenesis

    Page, DJ, Thuret, R, Venkatraman, L, Takahashi, T, Bentley, K and Herbert, SP (2019) Positive Feedback Defines the Timing, Magnitude, and Robustness of Angiogenesis. Cell Reports, 27 (11). 3139-3151.e5. ISSN 2211-1247

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    Abstract

    © 2019 The Authors In angiogenesis, tight control of endothelial tip cell selection and migration drives new blood vessel branching. Page et al. show that VEGF-signaling-mediated positive feedback shapes the timing, magnitude, and robustness of tip cell identity decisions. Moreover, they identify a key modulator of VEGF-mediated positive feedback, Tm4sf18, which temporally controls angiogenesis in vivo.

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