e-space
Manchester Metropolitan University's Research Repository

Positive Feedback Defines the Timing, Magnitude, and Robustness of Angiogenesis

Page, DJ, Thuret, R, Venkatraman, L, Takahashi, T, Bentley, K and Herbert, SP (2019) Positive Feedback Defines the Timing, Magnitude, and Robustness of Angiogenesis. Cell Reports, 27 (11). 3139-3151.e5. ISSN 2211-1247

[img]
Preview
Published Version
Available under License Creative Commons Attribution.

Download (5MB) | Preview

Abstract

© 2019 The Authors In angiogenesis, tight control of endothelial tip cell selection and migration drives new blood vessel branching. Page et al. show that VEGF-signaling-mediated positive feedback shapes the timing, magnitude, and robustness of tip cell identity decisions. Moreover, they identify a key modulator of VEGF-mediated positive feedback, Tm4sf18, which temporally controls angiogenesis in vivo.

Impact and Reach

Statistics

Activity Overview
6 month trend
178Downloads
6 month trend
207Hits

Additional statistics for this dataset are available via IRStats2.

Altmetric

Actions (login required)

View Item View Item