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    Positive Feedback Defines the Timing, Magnitude, and Robustness of Angiogenesis

    Page, DJ, Thuret, R, Venkatraman, L, Takahashi, T, Bentley, K and Herbert, SP (2019) Positive Feedback Defines the Timing, Magnitude, and Robustness of Angiogenesis. Cell Reports, 27 (11). 3139-3151.e5. ISSN 2211-1247

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    Abstract

    © 2019 The Authors In angiogenesis, tight control of endothelial tip cell selection and migration drives new blood vessel branching. Page et al. show that VEGF-signaling-mediated positive feedback shapes the timing, magnitude, and robustness of tip cell identity decisions. Moreover, they identify a key modulator of VEGF-mediated positive feedback, Tm4sf18, which temporally controls angiogenesis in vivo.

    Item Type: Article
    Peer-reviewed: Yes
    Date Deposited: 28 Jun 2019 09:08
    Publisher: Elsevier
    Additional Information: This is an Open Access article published in Cell Reports, published by Elsevier, copyright The Author(s).
    Divisions: Faculties > Science and Engineering
    Subject terms: angiogenesis, endothelial cell, lateral inhibition, positive feedback, tetraspanin, tip cell
    URI: https://e-space.mmu.ac.uk/id/eprint/623190
    DOI: https://doi.org/10.1016/j.celrep.2019.05.052
    ISSN 2211-1247
    e-ISSN 2211-1247

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