Neuroinflammation in mild cognitive impairment and Alzheimer's disease: a meta-analysis

Bradburn, Steven, Murgatroyd, Christopher ORCID: https://orcid.org/0000-0002-6885-7794 and Ray, Nicola ORCID: https://orcid.org/0000-0001-9645-0812 (2019) Neuroinflammation in mild cognitive impairment and Alzheimer's disease: a meta-analysis. Ageing Research Reviews, 50. pp. 1-8. ISSN 1568-1637

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Official URL: https://doi.org/10.1016/j.arr.2019.01.002

Abstract

BACKGROUND:Increasingly, evidence from brain imaging supports the role of neuroinflammation in dementia progression. Yet, it is not clear if there are patterns of spatial and temporal susceptibility to neuroinflammatory processes in the brain that may correspond to dementia staging or symptom expression. METHODS:We searched literature databases for case-control studies examining levels of translocator protein (TSPO) levels using positron emission tomography, representing neuroinflammation, in regional analyses between healthy controls and mild cognitive impairment (MCI) or Alzheimer's disease (AD) subjects. Standardised mean differences (SMDs) were calculated and results meta-analysed using random-effects models. Quality assessments, sensitivity analysis, subgroup analysis and meta-regressions were also performed. RESULTS:Twenty-eight studies comprising 755 (HC = 318, MCI = 168, AD = 269) participants and 37 brain regions were included. Compared to HCs, AD participants had increased TSPO levels throughout the brain (SMD range: 0.43 - 1.76), especially within fronto-temporal regions. MCI subjects also had increased TSPO levels, mainly within the neocortex, with more modest effects (SMD range: 0.46 - 0.90). Meta-regression analysis identified an inverse association between TSPO levels in the parietal region and Mini-Mental State Examination scores, a proxy for disease severity, in AD subjects (estimate: -0.11, 95% confidence interval: -0.21 to -0.02; P = 0.024). CONCLUSIONS:Our findings support the association of increased neuroinflammation during the progression of MCI and AD, relative to HCs.

Item Type:	Article
Peer-reviewed:	Yes
Date Deposited:	14 Jan 2019 12:16
Publisher:	Elsevier
Additional Information:	This is an Author Accepted Manuscript of a paper accepted for publication in Ageing Research Reviews, published by and copyright Elsevier.
Divisions:	Faculties > Health and Education Faculties > Science and Engineering
Subject terms:	Science & Technology, Life Sciences & Biomedicine, Cell Biology, Geriatrics & Gerontology, Mild cognitive impairment, Alzheimer's disease, Neuroinflammation, Positron-emission tomography, Inflammation, POSITRON-EMISSION-TOMOGRAPHY, PERIPHERAL BENZODIAZEPINE-RECEPTOR, MICROGLIAL ACTIVATION, TRANSLOCATOR PROTEIN, RADIOLIGAND BINDING, NEURONAL FUNCTION, REFERENCE REGION, HUMAN BRAIN, PET, TSPO, Brain, Humans, Alzheimer Disease, Disease Progression, Inflammation, Receptors, GABA, Positron-Emission Tomography, Case-Control Studies, Aged, Female, Male, Cognitive Dysfunction, Alzheimer’s disease, Inflammation, Mild cognitive impairment, Neuroinflammation, Positron-emission tomography, Aged, Alzheimer Disease, Brain, Case-Control Studies, Cognitive Dysfunction, Disease Progression, Female, Humans, Inflammation, Male, Positron-Emission Tomography, Receptors, GABA, 0601 Biochemistry and Cell Biology, 1103 Clinical Sciences, 1109 Neurosciences, Gerontology
URI:	https://e-space.mmu.ac.uk/id/eprint/622107
DOI:	https://doi.org/10.1016/j.arr.2019.01.002
ISSN	1568-1637
e-ISSN	1872-9649

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