Zeolite-embedded silver extends antimicrobial activity of dental acrylics

Malic, Sladjana, Rai, Sheela, Redfern, James, Pritchett, James, Liauw, Christopher, Verran, Joanna and Tosheva, Lubomira (2018) Zeolite-embedded silver extends antimicrobial activity of dental acrylics. Colloids and Surfaces B: Biointerfaces, 173. pp. 52-57. ISSN 0927-7765

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Abstract

The insertion of prosthetic devices into the oral cavity affects the oral microflora and results in accumulation of microorganisms on the prosthetic surface. Such fouling of denture surfaces can lead to a number of oral diseases and consequently to the replacement of the denture. Here, we report the post-synthesis introduction of silver in zeolite-loaded dental acrylic (DAZ) resins that does not influence the mechanical or aesthetic properties of the DA resins, and provides them with a long-term antimicrobial activity. Na-FAU zeolite (2 wt%) was incorporated into DA resin, which was conventionally processed and cut into 10 mm x 20 mm x 3 mm coupons. The Na+ in the zeolite was then exchanged with Ag+ via immersion of the DAZ coupons in 0.01 M AgNO3 solution to obtain DAZ/Ag-treated coupons used in antimicrobial tests. Antimicrobial tests showed that the DAZ/Ag-treated coupons were active against Candida albicans (a reference and a clinically relevant strain), Streptococcus mutans and Fusobacterium nucleatum. Ag leaching tests on the Ag-charged coupons at 1, 2, 3, 4, 7, 14, 30 and 45 days of incubation in distilled water at 37 °C, indicated sustained release of silver. Antimicrobial tests using a reference Candida albicans strain showed that the leached coupons retained antimicrobial activity after 45 days immersion in distilled water, but, after 60 days incubation no antimicrobial activity was observed. Cytotoxicity assay results indicated that the DAZ/Ag-treated coupons showed no additional cytotoxicity compared to neat dental acrylic coupons.

Item Type:	Article
Peer-reviewed:	Yes
Date Deposited:	21 Sep 2018 08:35
Publisher:	Elsevier
Additional Information:	This is an Author Accepted Manuscript of a paper accepted for publication in Colloids and Surfaces B: Biointerfaces, published by and copyright Elsevier.
Divisions:	Faculties > Science and Engineering Research Centres > Advanced Materials and Surface Engineering Research Centres > Centre for Bioscience Research Centres > Ecology and Environment Research Centre
Subject terms:	Dental acrylic resins, Zeolites, Ag ion-exchange, Long-term antimicrobial dentures;, Candida albicans, 0306 Physical Chemistry (Incl. Structural), 0903 Biomedical Engineering, 0904 Chemical Engineering, Chemical Physics
URI:	https://e-space.mmu.ac.uk/id/eprint/621494
DOI:	https://doi.org/10.1016/j.colsurfb.2018.09.043
ISSN	0927-7765

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