e-space
Manchester Metropolitan University's Research Repository

    Master athletes have higher miR-7, SIRT3 and SOD2 expression in skeletal muscle than age-matched sedentary controls.

    Koltai, E, Bori, Z, Osvath, P, Ihasz, F, Peter, S, Toth, G, Degens, Hans, Rittweger, J, Boldogh, I and Radak, Z (2018) Master athletes have higher miR-7, SIRT3 and SOD2 expression in skeletal muscle than age-matched sedentary controls. Redox biology, 19. pp. 46-51. ISSN 2213-2317

    [img]
    Preview
    Published Version
    Available under License Creative Commons Attribution.

    Download (650kB) | Preview

    Abstract

    Regular physical exercise has health benefits and can prevent some of the ageing-associated muscle deteriorations. However, the biochemical mechanisms underlying this exercise benefit, especially in human tissues, are not well known. To investigate, we assessed this using miRNA profiling, mRNA and protein levels of anti-oxidant and metabolic proteins in the vastus lateralis muscle of master athletes aged over 65 years and age-matched controls. Master athletes had lower levels of miR-7, while mRNA or protein levels of SIRT3, SIRT1, SOD2, and FOXO1 levels were significantly higher in the vastus lateralis muscle of master athletes compared to muscles of age-matched controls. These results suggest that regular exercise results in better cellular metabolism and antioxidant capacity via maintaining physiological state of mitochondria and efficient ATP production and decreasing ageing-related inflammation as indicated by the lower level of miR-7 in master athletes.

    Impact and Reach

    Statistics

    Activity Overview
    6 month trend
    439Downloads
    6 month trend
    307Hits

    Additional statistics for this dataset are available via IRStats2.

    Altmetric

    Repository staff only

    Edit record Edit record