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The cardiorespiratory response and physiological determinants of the assisted 6-minute handbike cycle test in adult males with muscular dystrophy.

Morse, Christopher I and Bostock, Emma L and Twiss, Harriet M and Kapp, Laura H and Orme, Paul and Jacques, Matthew F (2018) The cardiorespiratory response and physiological determinants of the assisted 6-minute handbike cycle test in adult males with muscular dystrophy. Muscle and Nerve, 58 (3). pp. 427-433. ISSN 0148-639X

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Abstract

Assisted six-minute cycle test (A6MCT) distance was assessed in adults with muscular dystrophy (MD).Forty-eight males, including Duchenne (DMD), limb-girdle (LGMD), fascioscapulohumeral (FSHD), Becker (BMD), and non-MD (CTRL), completed handgrip strength (HGS), lung function (FEV1, FVC), body fat and biceps thickness assessments. During the A6MCT, ventilation (VE), oxygen uptake (VO2 ), carbon dioxide (VCO2 ) and heart rate (HR) were recorded.A6MCT and HGS were less in MD than CTRL. FEV1 , FVC and biceps thickness were lower in MD than CTRL, lower in DMD than BMD, LGMD and FSHD, but not different between BMD, LGMD, and FSHD. A6MCT correlated with HGS, FEV1 , FVC, body fat, VO2 , VCO2 , HR, and VE (r=0.455-0.708) in pooled BMD, LGMD, and FSHD participants.A lower A6MCT distance in adult males with MD was attributable to HGS and lung function. The A6MCT is appropriate for the assessment of physical function in adults with MD. This article is protected by copyright. All rights reserved.

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