Toxic shock syndrome toxin-1 (TSST-1) antibody levels in burned children

Childs, Charmaine, Edwards-Jones, Valerie, Dawson, Maureen M. and Davenport, Peter J. (1999) Toxic shock syndrome toxin-1 (TSST-1) antibody levels in burned children. Burns, 25 (6). pp. 473-476. ISSN 0305-4179

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Abstract

Young children with burns are at risk of developing a toxic shock-like illness during the first 2–3 days after the injury. The staphylococcal exotoxin, toxic-shock syndrome toxin-1 (TSST-1) is implicated in development of this illness. Low levels or absence of anti-TSST-1 antibodies may indicate susceptibility to this illness. Anti-TSST-1 antibody levels were measured in consecutive cases admitted to the children’s burns unit. Results of antibody levels in 38 of the youngest children, aged 0.04–4.0 years are reported. At the time of admission to the unit 50% of the children had IgG antibodies to TSST-1. A higher number of young burned children had antibodies to TSST-1 than expected.