Manchester Metropolitan University's Research Repository

The impact of azithromycin therapy on the airway microbiota in asthma

Slater, M, Rivett, DW, Williams, L, Martin, M, Harrison, T, Sayers, I, Bruce, KD and Shaw, D (2014) The impact of azithromycin therapy on the airway microbiota in asthma. Thorax, 69 (7). pp. 673-674. ISSN 1468-3296


Available under License Creative Commons Attribution Non-commercial.

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There is interest in the use of macrolide antibiotics in asthma. Macrolides have been shown to improve airway hyper-responsiveness (AHR) and measures of airway inflammation.1 The degree of AHR may relate to the microbiota present in the airways,2 with a recent study reporting that patients with asthma with a significant improvement in AHR following treatment with clarithromycin had a higher bacterial diversity prior to treatment.3 To our knowledge, the impact on the asthmatic airway microbiota of an antibiotic has not been reported and we therefore set out to establish if macrolide therapy was associated with a change in airway microbiota in asthma.

Impact and Reach


Activity Overview
6 month trend
6 month trend

Additional statistics for this dataset are available via IRStats2.


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