e-space
Manchester Metropolitan University's Research Repository

    Model for a population-based microbial oscillator

    Goni-Moreno, A and Amos, M (2011) Model for a population-based microbial oscillator. BioSystems, 105 (3). pp. 286-294. ISSN 0303-2647

    [img]
    Preview
    Accepted Version
    Available under License Creative Commons Attribution Non-commercial No Derivatives.

    Download (837kB) | Preview

    Abstract

    Genetic oscillators are a major theme of interest in the emerging field of synthetic biology. Until recently, most work has been carried out using intra-cellular oscillators, but this approach restricts the broader applicability of such systems. Motivated by a desire to develop large-scale, spatially distributed cell-based computational systems, we present an initial design for a population-level oscillator which uses three different bacterial strains. Our system is based on the client–server model familiar to computer science, and uses quorum sensing for communication between nodes. Importantly, it is robust to perturbation and noise. We present the results of extensive in silico simulation tests, which confirm the feasibility of our design.

    Impact and Reach

    Statistics

    Activity Overview
    6 month trend
    242Downloads
    6 month trend
    268Hits

    Additional statistics for this dataset are available via IRStats2.

    Altmetric

    Repository staff only

    Edit record Edit record