Preparation of chitosan grafted graphite composite for sensitive detection of dopamine in biological samples

Palanisamy, S, Thangavelu, K, Chen, SM, Gnanaprakasam, P, Velusamy, V and Liu, XH (2016) Preparation of chitosan grafted graphite composite for sensitive detection of dopamine in biological samples. Carbohydrate Polymers, 151. pp. 401-407. ISSN 0144-8617

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Official URL: https://doi.org/10.1016/j.carbpol.2016.05.076

Abstract

© 2016 Elsevier Ltd. All rights reserved.The accurate detection of dopamine (DA) levels in biological samples such as human serum and urine are essential indicators in medical diagnostics. In this work, we describe the preparation of chitosan (CS) biopolymer grafted graphite (GR) composite for the sensitive and lower potential detection of DA in its sub micromolar levels. The composite modified electrode has been used for the detection of DA in biological samples such as human serum and urine. The GR-CS composite modified electrode shows an enhanced oxidation peak current response and low oxidation potential for the detection of DA than that of electrodes modified with bare, GR and CS discretely. Under optimum conditions, the fabricated GR-CS composite modified electrode shows the DPV response of DA in the linear response ranging from 0.03 to 20.06 μM. The detection limit and sensitivity of the sensor were estimated as 0.0045 μM and 6.06 μA μM-1 cm-2, respectively.

Item Type:	Article (Article)
Peer-reviewed:	Yes
Date Deposited:	01 Dec 2017 10:01
Publisher:	Elsevier
Additional Information:	This is an Author Accepted Manuscript of a paper accepted for publication in Carbohydrate Polymers, published by and copyright Elsevier.
Divisions:	Faculties > Science and Engineering
Subject terms:	Science & Technology, Physical Sciences, Chemistry, Applied, Chemistry, Organic, Polymer Science, Chemistry, Graphite, Chitosan, Biopolymer, Dopamine, Electro-oxidation, Differential pulse voltammetry, CARBON-PASTE ELECTRODE, ASCORBIC-ACID, URIC-ACID, ELECTROCHEMICAL BIOSENSOR, GRAPHENE, MORPHINE, TYROSINASE, NANOTUBES, SENSOR, IMMOBILIZATION, Biopolymer, Chitosan, Differential pulse voltammetry, Dopamine, Electro-oxidation, Graphite, 0305 Organic Chemistry, 0908 Food Sciences, 0303 Macromolecular And Materials Chemistry, Polymers
URI:	https://e-space.mmu.ac.uk/id/eprint/619514
DOI:	https://doi.org/10.1016/j.carbpol.2016.05.076
ISSN	0144-8617

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