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    Bisphosphonate-related osteonecrosis of jaw (BRONJ): an anti-angiogenic side-effect?

    Petcu, EB, Ivanovski, S, Wright, RG, Slevin, M, Miroiu, RI and Brinzaniuc, K (2012) Bisphosphonate-related osteonecrosis of jaw (BRONJ): an anti-angiogenic side-effect? Diagnostic Pathology, 7. ISSN 1746-1596

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    Abstract

    Bisphosphonates are recommended in the treatment of osteoporosis and some cancers, in which case they prevent the appearance of bone metastasis. The patients taking bisphosphonates are at increased risk of developing bisphosphonate-related osteonecrosis of jaw (BRONJ) which is characterised by the presence of an un-healing wound after dental surgery. BRONJ might represent an anti-angiogenic side effect. However, the real number of patients with BRONJ might be higher than currently recorded. Considering the differential diagnosis which includes various primary and secondary cancers, a correct histopathological diagnosis is very important. The morphological criteria for diagnosis of BRONJ are highlighted in this material.Virtual Slides: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1813972972323288. © 2012 Petcu et al.; licensee BioMed Central Ltd.

    Item Type: Article
    Peer-reviewed: Yes
    Date Deposited: 10 May 2017 07:47
    Publisher: BioMed Central
    Additional Information: This is an Open Access article published in Diagnostic Pathology, published by BioMed Central , copyright Petcu et al.; licensee BioMed Central Ltd. 2012.
    Divisions: Faculties > Science and Engineering
    Subject terms: Science & Technology, Life Sciences & Biomedicine, Pathology, PATHOLOGY, BONE METASTASES, BREAST-CANCER, PREVENTION, Facial Bones, Humans, Biological Markers, Biopsy, Predictive Value of Tests, Wound Healing, Neovascularization, Physiologic, Bisphosphonate-Associated Osteonecrosis of the Jaw, Biomarkers, Biopsy, Bisphosphonate-Associated Osteonecrosis of the Jaw, Facial Bones, Humans, Neovascularization, Physiologic, Predictive Value of Tests, Wound Healing, Pathology
    URI: https://e-space.mmu.ac.uk/id/eprint/618407
    DOI: https://doi.org/10.1186/1746-1596-7-78
    ISSN 1746-1596

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