Expression of monomeric C-reactive protein in infarcted brain tissue from patients with Alzheimer’s disease

Liu, D, Slevin, M, Ferris, G, Al-Hsinawi, M, Al-Baradie, R and Krupinski, J (2017) Expression of monomeric C-reactive protein in infarcted brain tissue from patients with Alzheimer’s disease. Turkish Journal of Pathology, 33 (1). pp. 25-29. ISSN 1309-5730

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Abstract

Objective: We have previously shown that monomeric-C-reactive protein is deposited in significant quantities within the brain parenchyma after stroke. Since we have recently identified a possible role of this protein in supporting neurodegeneration and aberrant vascular development, we identified a small group of post-mortem brain samples from individuals who had Alzheimer’s disease and evidence of tissue infarction/ micro-infarction on histological examination. Material and Method: We used immunohistochemistry staining to identify the monomeric-C-reactive protein expressed in the infarcted brain tissues. Results: We showed that monomeric-C-reactive protein deposition was highest in those regions affected by stroke or vascular disruption, and that within those same areas, there was more interaction and co-localization between major classical proteins of neurodegeneration (β-amyloid and tau). Conclusion: We hypothesise that vascular disruption and concomitant release of monomeric-C-reactive protein within the brain tissue could exacerbate ongoing neurological damage via stimulation of neuro-inflammation and from direct consequences of its action on both neuronal and vascular cells.