e-space
Manchester Metropolitan University's Research Repository

The influence of silica nanoparticles on small mesenteric arterial function

Shukur, A and Whitehead, D and Seifalian, A and Azzawi, M (2016) The influence of silica nanoparticles on small mesenteric arterial function. Nanomedicine, 11 (16). pp. 2131-2146. ISSN 1743-5889

[img]
Preview

Download (676kB) | Preview

Abstract

Aim: To determine the influence of silica nanoparticles (SiNPs) on small arterial function; both ex vivo and in vivo. Methods: Mono-dispersed dye-encapsulated SiNPs (97.85 ± 2.26 nm) were fabricated and vasoconstrictor and vasodilator responses of mesenteric arteries assessed. Results: We show that while exposure to SiNPs under static conditions, attenuated endothelial dependent dilator responses ex vivo, attenuation was only evident at lower agonist concentrations, when exposed under flow conditions or after intravenous administration in vivo. Pharmacological inhibition studies suggest that SiNPs may interfere with the endothelial dependent hyperpolarizing factor vasodilator pathway. Conclusion: The dosage dependent influence of SiNPs on arterial function will help identify strategies for their safe clinical administration.

Impact and Reach

Statistics

Downloads
Activity Overview
25Downloads
43Hits

Additional statistics for this dataset are available via IRStats2.

Altmetric

Actions (login required)

Edit Item Edit Item