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Catalytic Synthesis of Enantiopure Chiral Alcohols via Addition of Grignard Reagents to Carbonyl Compounds

Collados, JF and Solaì, R and Harutyunyan, SR and Maciá, B (2016) Catalytic Synthesis of Enantiopure Chiral Alcohols via Addition of Grignard Reagents to Carbonyl Compounds. ACS Catalysis, 6 (3). pp. 1952-1970. ISSN 2155-5435

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Abstract

© 2016 American Chemical Society.Remarkable progress in the enantioselective addition of Grignard reagents to carbonyl compounds has been made over the past decade. This enantioselective transformation now allows the use of these challenging reactive nucleophiles for the formation of chiral alcohols using catalytic amounts of chiral ligands. This review summarizes the developments in this area.

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