Catalytic Synthesis of Enantiopure Chiral Alcohols via Addition of Grignard Reagents to Carbonyl Compounds

Collados, JF, Solaì, R, Harutyunyan, SR and Maciá, B (2016) Catalytic Synthesis of Enantiopure Chiral Alcohols via Addition of Grignard Reagents to Carbonyl Compounds. ACS Catalysis, 6 (3). pp. 1952-1970. ISSN 2155-5435

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Official URL: https://pubs.acs.org/doi/10.1021/acscatal.5b02832

Abstract

Remarkable progress in the enantioselective addition of Grignard reagents to carbonyl compounds has been made over the past decade. This enantioselective transformation now allows the use of these challenging reactive nucleophiles for the formation of chiral alcohols using catalytic amounts of chiral ligands. This review summarizes the developments in this area.

Item Type:	Article
Peer-reviewed:	Yes
Date Deposited:	12 Apr 2017 08:02
Publisher:	American Chemical Society
Additional Information:	This document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Catalysis, copyright © 2016 American Chemical Society, after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acscatal.5b02832
Divisions:	Faculties > Science and Engineering
Subject terms:	Science & Technology, Physical Sciences, Chemistry, Physical, Chemistry, Grignard reagents, carbonyl compound, 1,2-addition reaction, enantioselective catalysis, titanium, copper, HIGHLY ENANTIOSELECTIVE ADDITION, CROSS-COUPLING REACTIONS, ASYMMETRIC ADDITION, ORGANOMAGNESIUM REAGENTS, DIORGANOZINC REAGENTS, TITANIUM COMPLEXES, TRIALKYLALUMINUM ADDITION, ORGANOMETALLIC REAGENTS, ORGANOZINC REAGENTS, EXCHANGE-REACTION, 0302 Inorganic Chemistry, 0305 Organic Chemistry, 0904 Chemical Engineering
URI:	https://e-space.mmu.ac.uk/id/eprint/593
DOI:	https://doi.org/10.1021/acscatal.5b02832
ISSN	2155-5435
e-ISSN	2155-5435

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