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New VEGF antagonists as possible therapeutic agents in vascular disease

Slevin, Mark and Kumar, Patricia and Wang, Qiuyu and Kumar, Shant and Gaffney, John and Grau-Olivares, Marta and Krupinski, Jerzy (2008) New VEGF antagonists as possible therapeutic agents in vascular disease. Expert opinion on investigational drugs, 17 (9). pp. 1301-1314. ISSN 1354-3784

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BACKGROUND: In this review we provide the reader with an analysis of the importance of VEGF in modulating the angiogenic process in vascular diseases. OBJECTIVES: We have described the key role of VEGF in the development of the major angiogenic diseases including ocular retinopathies, solid tumour growth and atherosclerotic plaque development. METHODS: Following a brief description of the disease, a detailed literature review of the mechanisms through which VEGF induces promotion of neovascularisation and current anti-VEGF therapies is provided for the reader. RESULTS/CONCLUSIONS: Current and future potential clinical therapies are discussed in particular concerning our thoughts on future directives involving adenoviral-mediated gene targeting, nanotechnology and combinational therapies.

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