e-space
Manchester Metropolitan University's Research Repository

    Genetic variation, protein composition and potential influences on tendon properties in humans

    Foster, B. P., Morse, Christopher I., Onambele-Pearson, Gladys, Ahmetov, Ildus I. and Williams, Alun G. (2012) Genetic variation, protein composition and potential influences on tendon properties in humans. The open sports medicine journal, 6 (1). pp. 8-21. ISSN 1874-3870

    [img]
    Preview

    Available under License In Copyright.

    Download (1MB) | Preview

    Abstract

    Sequence variations in genes that code for proteins involved in homeostatic processes within tendons may influence tendon mechanical properties. Since variants of the four genes COL5A1, TNC, MMP3 and GDF5 have been implicated in the aetiopathogenesis of tendinopathies, which is ultimately characterised by abnormal structural and regulatory processes, sequence variations in these four genes may also influence how the tendon functions mechanically, even in the absence of tendinopathy. For example, two reports of association between variation in the COL5A1 gene and measures of flexibility complement reported associations between genotype and incidence of tendinopathy. Non-genetic factors such as age, body mass and physical activity status influence risk of tendon injury and physical performance potential independently from genomics, and also in gene-environment interactions. However, these non-genetic factors are often not considered in genetic association studies, probably due to their retrospective nature. Further research examining COL5A1, TNC, MMP3 and GDF5, as well as other genes that may influence the maintenance of tendon homeostasis such as COL1A1 which regulates the production of collagen type 1, the most abundant structural component of tendon is encouraged. Establishing the genetic basis of tendon properties in asymptomatic populations may advance understanding of some aspects relevant to physical performance and of the aetiology of tendinopathies. To improve understanding, accurate and reproducible assessments of tendon properties are required. However, no valid and reliable assessments of tendon properties, such as those involving in vivo ultrasound imaging techniques, have yet been applied to genetic association studies in humans.

    Impact and Reach

    Statistics

    Activity Overview
    6 month trend
    290Downloads
    6 month trend
    433Hits

    Additional statistics for this dataset are available via IRStats2.

    Altmetric

    Repository staff only

    Edit record Edit record