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Synthesis of Functionalized Isoindolinones via Calcium Catalyzed Generation and Trapping of N-Acyliminium Ions

Basson, Ashley and McLaughlin, Mark Gerard (2020) Synthesis of Functionalized Isoindolinones via Calcium Catalyzed Generation and Trapping of N-Acyliminium Ions. The Journal of Organic Chemistry. ISSN 0022-3263

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Abstract

Herein we report our full investigation into the calcium catalyzed generation and trapping of N-acyliminium ions from readi-ly available 3-hydroxyisoindolinones. We have successfully employed a range of traditional nucleophiles including carbon, nitrogen and sulfur containing reactive partners. The reaction is tolerant to a wide range of functionalities and provides high value scaffolds in good to excellent yields

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