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Functionalisation of Isoindolinones via a Calcium Catalysed Hosomi-Sakurai Allylation

Basson, Ashley James and McLaughlin, Mark G (2019) Functionalisation of Isoindolinones via a Calcium Catalysed Hosomi-Sakurai Allylation. Chemical Communications, 55. ISSN 1359-7345

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Abstract

A rapid and functionally tolerant calcium catalysed Hosomi-Sakurai reaction has been realised. Employing 1 mol% calcium, allylated isoindolinones can be synthesised in high yields and the reaction is shown to be tolerant to a range of medicinally relevant functional groups including heterocycles. The synthetic utility of the reaction has been shown, and a plausible reaction mechanism is provided.

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