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    Dibenzoyl-methane derivatives as a potential and exciting new therapy for the treatment of childhood bone cancer

    Almelah, E, Smith, DPT, McGown, A, Aziz, A, Potgieter, JH and Ragazzon, P (2016) Dibenzoyl-methane derivatives as a potential and exciting new therapy for the treatment of childhood bone cancer. Anticancer Research, 36 (11). pp. 6043-6050. ISSN 0250-7005

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    Abstract

    Childhood bone cancer though rare, has very limited treatment choices, with poor survival rates and often involving amputation. We developed a novel molecule, 2′,4′-dihydroxy-dithion-dibenzoyl-methane and tested it on hepatic, colon, lung and osteoblast cancer cell lines. Thionylation of 2′,4′-dihydroxydibenzoylmethane led to selective targeting of bone cancer cells, stopping their growth and leading to their death without affecting non-cancerous cells within the bone marrow or other non-malignant cells.

    Item Type: Article
    Peer-reviewed: Yes
    Date Deposited: 16 Feb 2017 08:53
    Publisher: International Institute of Anticancer Research
    Additional Information: This is an Author Accepted Manuscript of a paper accepted for publication in Anticancer Research, published by and copyright International Institute of Anticancer Research.
    Divisions: Faculties > Science and Engineering
    Research Centres > Advanced Materials and Surface Engineering
    Subject terms: 1112 Oncology And Carcinogenesis, Oncology & Carcinogenesis
    URI: https://e-space.mmu.ac.uk/id/eprint/617845
    DOI: https://doi.org/10.21873/anticanres.11193
    ISSN 0250-7005

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