Flüeck, Martin and Schmutz, Silvia and Däpp, Christoph and Wittwer, Matthias and Vogt, Michael and Hoppeler, Hans (2006) Endurance training modulates the muscular transcriptome response to acute exercise. ISSN 1432-2013Full text not available from this repository.
We hypothesized that in untrained individuals (n=6) a single bout of ergometer endurance exercise provokes a concerted response of muscle transcripts towards a slow-oxidative muscle phenotype over a 24-h period. We further hypothesized this response during recovery to be attenuated after six weeks of endurance training. We monitored the expression profile of 220 selected transcripts in muscle biopsies before as well as 1, 8, and 24 h after a 30-min near-maximal bout of exercise. The generalized gene response of untrained vastus lateralis muscle peaked after 8 h of recovery (P=0.001). It involved multiple transcripts of oxidative metabolism and glycolysis. Angiogenic and cell regulatory transcripts were transiently reduced after 1 h independent of the training state. In the trained state, the induction of most transcripts 8 h after exercise was less pronounced despite a moderately higher relative exercise intensity, partially because of increased steady-state mRNA concentration, and the level of metabolic and extracellular RNAs was reduced during recovery from exercise. Our data suggest that the general response of the transcriptome for regulatory and metabolic processes is different in the trained state. Thus, the response is specifically modified with repeated bouts of endurance exercise during which muscle adjustments are established.
|Additional Information:||Citation: Pflügers archiv - European journal of physiology, 2006, vol. 451, no. 5, pp. 678-687.|
|Divisions:||Faculties > Faculty of Science and Engineering > Department of Biological Sciences|
|Date Deposited:||20 Jan 2010 14:09|
|Last Modified:||20 Jul 2016 01:17|
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