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    An efficient preparation of 1,2-dihydropyridazines through a Diels-Alder/palladium-catalysed elimination sequence

    Britten, TK ORCID logoORCID: https://orcid.org/0000-0002-3580-1145, Akien, GR, Kemmitt, PD, Halcovitch, NR and Coote, SC (2019) An efficient preparation of 1,2-dihydropyridazines through a Diels-Alder/palladium-catalysed elimination sequence. Tetrahedron Letters, 60 (22). pp. 1498-1500. ISSN 0040-4039

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    Abstract

    © 2019 Elsevier Ltd A convenient, scalable synthesis of 1,2-dihydropyridazines is presented, based on the Diels-Alder cycloaddition of 1-acetoxy-1,3-butadiene with a variety of azo compounds, followed by a palladium-catalysed elimination. The products are produced on multigram scale and the new method is particularly efficient and atom-economical when compared with previous preparations of 1,2-dihydropyridazines.

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