e-space
Manchester Metropolitan University's Research Repository

Hyperpolarization of Pyridyl Fentalogues by Signal Amplification By Reversible Exchange (SABRE)

Robertson, TBR and Antonides, LH and Gilbert, N and Benjamin, SL and Langley, SK and Munro, LJ and Sutcliffe, OB and Mewis, RE (2019) Hyperpolarization of Pyridyl Fentalogues by Signal Amplification By Reversible Exchange (SABRE). ChemistryOpen, 8. pp. 1-9.

[img]
Preview

Available under License Creative Commons Attribution Non-commercial No Derivatives.

Download (846kB) | Preview

Abstract

© 2019 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. Fentanyl, also known as ‘jackpot’, is a synthetic opiate that is 50–100 times more potent than morphine. Clandestine laboratories produce analogues of fentanyl, known as fentalogues to circumvent legislation regarding its production. Three pyridyl fentalogues were synthesized and then hyperpolarized by signal amplification by reversible exchange (SABRE) to appraise the forensic potential of the technique. A maximum enhancement of -168-fold at 1.4 T was recorded for the ortho pyridyl 1H nuclei. Studies of the activation parameters for the three fentalogues revealed that the ratio of ligand loss trans to hydride and hydride loss in the complex [Ir(IMes)(L)3(H)2]+ (IMes=1,3-bis(2,4,6-trimethylphenyl)imidazole-2-ylidene) ranged from 0.52 to 1.83. The fentalogue possessing the ratio closest to unity produced the largest enhancement subsequent to performing SABRE at earth's magnetic field. It was possible to hyperpolarize a pyridyl fentalogue selectively from a matrix that consisted largely of heroin (97 : 3 heroin:fentalogue) to validate the use of SABRE as a forensic tool.

Impact and Reach

Statistics

Downloads
Activity Overview
53Downloads
97Hits

Additional statistics for this dataset are available via IRStats2.

Altmetric

Actions (login required)

Edit Item Edit Item