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NR4A Nuclear Receptors Target Poly-ADP-Ribosylated DNA-PKcs Protein to Promote DNA Repair

Munnur, D and Somers, J and Skalka, G and Weston, R and Jukes-Jones, R and Bhogadia, M and Dominguez, C and Cain, K and Ahel, I and Malewicz, M (2019) NR4A Nuclear Receptors Target Poly-ADP-Ribosylated DNA-PKcs Protein to Promote DNA Repair. Cell Reports, 26 (8). 2028-2036.e6.

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Abstract

© 2019 The Author(s) DNA damage induces poly-ADP-ribosylation (PARylation) of repair factors recruited to DNA lesions. Munnur et al. identify a zinc-finger-type poly-ADP-ribose-binding domain in NR4A nuclear orphan receptors that targets PARylated DNA-PKcs repair kinase, facilitating its autophosphorylation and repair of double-strand DNA breaks.

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