NR4A Nuclear Receptors Target Poly-ADP-Ribosylated DNA-PKcs Protein to Promote DNA Repair

Munnur, D and Somers, J and Skalka, G and Weston, R and Jukes-Jones, R and Bhogadia, M and Dominguez, C and Cain, K and Ahel, I and Malewicz, M (2019) NR4A Nuclear Receptors Target Poly-ADP-Ribosylated DNA-PKcs Protein to Promote DNA Repair. Cell Reports, 26 (8). 2028-2036.e6.

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Abstract

© 2019 The Author(s) DNA damage induces poly-ADP-ribosylation (PARylation) of repair factors recruited to DNA lesions. Munnur et al. identify a zinc-finger-type poly-ADP-ribose-binding domain in NR4A nuclear orphan receptors that targets PARylated DNA-PKcs repair kinase, facilitating its autophosphorylation and repair of double-strand DNA breaks.

Item Type:	Article
Peer-reviewed:	Yes
Publisher:	Elsevier
Additional Information:	This is an Open Access article published in Cell Reports by Elsevier.
Divisions:	Faculties > Science and Engineering Research Centres > Centre for Bioscience
Subject terms:	Science & Technology, Life Sciences & Biomedicine, Cell Biology, STRAND BREAK REPAIR, DAMAGE RESPONSE, MECHANISM, ARTEMIS, DOMAINS, APLF, KU, DNA repair, DNA-PK, DSB, NHEJ, NR4A, PARP, double-strand breaks, non-homologous end joining, poly-ADP-ribose, transcription factors
URI:	https://e-space.mmu.ac.uk/id/eprint/622857
DOI:	https://doi.org/10.1016/j.celrep.2019.01.083
e-ISSN	2211-1247

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