e-space
Manchester Metropolitan University's Research Repository

Effectiveness of titanium nitride silver coatings against Staphylococcus spp. in the presence of BSA and whole blood conditioning agents

Saubade, FJ and Hughes, S and Wickens, DJ and Wilson-Nieuwenhuis, J and Dempsey-Hibbert, N and Crowther, G and West, G and Kelly, P and Banks, CE and Whitehead, KA (2018) Effectiveness of titanium nitride silver coatings against Staphylococcus spp. in the presence of BSA and whole blood conditioning agents. International Biodeterioration and Biodegradation. ISSN 0964-8305

This is the latest version of this item.

[img]
Available under License : See the attached licence file.

Download (787kB)

Abstract

Implanted medical devices are at risk of developing an infection at the surgical site. Once a medical implant is inserted, it initially becomes coated by a conditioning film, followed by bacterial retention. In the present study, medical grade stainless steel substrata were coated with titanium nitride (TiN) or titanium nitride/silver (TiN/14.94 at.%Ag or TiN/19.04 at.%Ag). Surface analysis determined that with increased silver concentration, silver nanoparticles were heterogeneously distributed throughout the coatings. The effect of bovine serum albumin or whole blood conditioning agents on the antimicrobial activity and microbial retention were determined using Staphylococcus aureus or Staphylococcus epidermidis. The presence of the conditioning agents reduced the antimicrobial effect of the surfaces against S. aureus. When the cells and conditioning agents were applied together, a reduction in bacterial retention and conditioning film was observed. These results suggest that the impact of conditioning agents should be considered since conditioning films may reduce bacterial retention but may also decrease the antimicrobial properties of the surface coatings.

Impact and Reach

Statistics

Downloads
Activity Overview
43Downloads
68Hits

Additional statistics for this dataset are available via IRStats2.

Altmetric

Available Versions of this Item

Actions (login required)

Edit Item Edit Item