e-space
Manchester Metropolitan University's Research Repository

Stem cell therapies in preclinical models of stroke. Is the aged brain microenvironment refractory to cell therapy?

Sandu, RE and Balseanu, AT and Bogdan, C and Slevin, M and Petcu, E and Popa-Wagner, A (2016) Stem cell therapies in preclinical models of stroke. Is the aged brain microenvironment refractory to cell therapy? Experimental Gerontology. ISSN 0531-5565

[img]
Preview

Available under License Creative Commons Attribution Non-commercial No Derivatives.

Download (568kB) | Preview

Abstract

© 2017.Stroke is a devastating disease demanding vigorous search for new therapies. Initial enthusiasm to stimulate restorative processes in the ischemic brain by means of cell-based therapies has meanwhile converted into a more balanced view recognizing impediments that may be related to unfavorable age-associated environments. Recent results using a variety of drug, cell therapy or combination thereof suggest that, (i) treatment with Granulocyte-Colony Stimulating Factor (G-CSF) in aged rats has primarily a beneficial effect on functional outcome most likely via supportive cellular processes such as neurogenesis; (ii) the combination therapy, G-CSF with mesenchymal cells (G-CSF + BM-MSC or G-CSF + BM-MNC) did not further improve behavioral indices, neurogenesis or infarct volume as compared to G-CSF alone in aged animals; (iii) better results with regard to integration of transplanted cells in the aged rat environment have been obtained using iPS of human origin; (iv) mesenchymal cells may be used as drug carriers for the aged post-stroke brains. Conclusion: While the middle aged brain does not seem to impair drug and cell therapies, in a real clinical practice involving older post-stroke patients, successful regenerative therapies would have to be carried out for a much longer time.

Impact and Reach

Statistics

Downloads
Activity Overview
51Downloads
73Hits

Additional statistics for this dataset are available via IRStats2.

Altmetric

Actions (login required)

Edit Item Edit Item