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    The influence of silica nanoparticles on small mesenteric arterial function

    Shukur, A, Whitehead, D, Seifalian, A and Azzawi, M (2016) The influence of silica nanoparticles on small mesenteric arterial function. Nanomedicine, 11 (16). pp. 2131-2146. ISSN 1743-5889

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    Abstract

    Aim: To determine the influence of silica nanoparticles (SiNPs) on small arterial function; both ex vivo and in vivo. Methods: Mono-dispersed dye-encapsulated SiNPs (97.85 ± 2.26 nm) were fabricated and vasoconstrictor and vasodilator responses of mesenteric arteries assessed. Results: We show that while exposure to SiNPs under static conditions, attenuated endothelial dependent dilator responses ex vivo, attenuation was only evident at lower agonist concentrations, when exposed under flow conditions or after intravenous administration in vivo. Pharmacological inhibition studies suggest that SiNPs may interfere with the endothelial dependent hyperpolarizing factor vasodilator pathway. Conclusion: The dosage dependent influence of SiNPs on arterial function will help identify strategies for their safe clinical administration.

    Item Type: Article
    Peer-reviewed: Yes
    Date Deposited: 29 Sep 2016 13:57
    Publisher: Future Medicine Ltd.
    Additional Information: This is an author accepted manuscript of a paper accepted for publication in Nanomedicine, published by and copyright Future Medicine Ltd.
    Divisions: Faculties > Science and Engineering
    Research Centres > Advanced Materials and Surface Engineering
    Research Centres > Centre for Bioscience
    Subject terms: EDHF, mesenteric artery, nanomedicine, silica nanoparticles, vasoconstriction, vasodilation, nanoparticle, vessel function, dilation, mesenteric, Nanoscience & Nanotechnology, 1004 Medical Biotechnology, 1007 Nanotechnology
    URI: https://e-space.mmu.ac.uk/id/eprint/617201
    DOI: https://doi.org/10.2217/nnm-2016-0124
    ISSN 1743-5889

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