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Endurance enhancement related to the human angiotensin I-converting enzyme I-D polymorphism is not due to differences in the cardiorespiratory response to training

Woods, David R. and World, Michael and Rayson, Mark P. and Williams, Alun G. and Jubb, Mick and Jamshidi, Yalda and Hayward, Marianne and Mary, David A.S.G. and Humphries, Steven E. and Montgomery, Hugh E. (2002) Endurance enhancement related to the human angiotensin I-converting enzyme I-D polymorphism is not due to differences in the cardiorespiratory response to training. European journal of applied physiology, 86 (3). pp. 240-244. ISSN 1439-6319

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Abstract

Human physical performance is strongly influenced by genetic factors. We have previously reported that the I variant of the human angiotensin I-converting enzyme (ACE) gene is associated with greater endurance performance in mountaineers and Olympic runners and improved performance in army recruits. In this study we examined whether this effect is mediated by improvements in cardiovascular fitness with training in 58 army recruits homozygous for the insertion (I, ACE genotype II) or deletion (D, ACE genotype DD) allele. A submaximal and maximal exercise protocol was used to calculate both the heart rate/oxygen uptake (VO2) relationship and changes in maximal oxygen uptake (VO2max), respectively. There was no significant inter-group difference in VO2max at baseline (P=0.19) or after training (P=0.22). There was no difference between genotypes with training in the heart rate/VO2 elevation (P=0.79 for the mean difference in mean adjusted heart rates). However, VO2 at all exercise intensities in the submaximal test was lower for all subjects after training compared to DD subjects [mean(SEM)] [1.6 (0.27) and 0.68 (0.27) ml kg -1 min -1, respectively; P=0.02 for mean difference]. The I/D polymorphism nay play a role in enhanced endurance performance but this is not mediated by differences in VO2max or the heart rate/Vo2 relationship in response to training.

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